Mayo Clinic Discovers Two Key Players In Cancer Prevention And How They Work
Mayo Clinic Discovers Two Key Players In Cancer Prevention And How They Work: "These new cancer players comprise a two-protein complex Rae1-Nup98. This complex works together to stabilize healthy cells by functioning as a kind of cell-division auditing system that makes sure the right number of chromosomes is distributed in each part of a newly divided cell. By so doing, they promote 'euploidy' -- the ideal chromosomal distribution needed for stability, and the opposite of aneuploidy.
"What we discovered is that there's an active process of cellular machinery that prevents aneuploidy," says Mayo cancer researcher Jan van Deursen, Ph.D., who led the research team. "It's a surveillance mechanism involving the two proteins Rae1-Nup98 that makes sure that in every cell division the proper number of chromosomes occur.""
"What we discovered is that there's an active process of cellular machinery that prevents aneuploidy," says Mayo cancer researcher Jan van Deursen, Ph.D., who led the research team. "It's a surveillance mechanism involving the two proteins Rae1-Nup98 that makes sure that in every cell division the proper number of chromosomes occur.""