Molecular Biology

Molecular Genetics

capping

Capping is a form of RNA processing in which the 5’ end of the nascent pre-mRNA is capped with a 7-methyl guanosine nucleotide, 7-methylguanylate. Capping occurs shortly after initiation of transcription.

The 5' cap is retained in mature mRNAs. Capping is required to protect the RNA transcript from degradation. It plays an important role in mRNA transport to the cytoplasm and in the initiation of protein synthesis (translation) .

life cycle of an mRNA ~ click on Quicktime QNCBI Molecular Cell Biology Post-transcriptional Processing of RNAs

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